Molecular mechanism of transforming growth factor-β on promoting corneal stroma scarring

VernacularTitle:转化生长因子-β促角膜基质瘢痕形成的分子机制
Author: Shinan, LUO
Publication Type:Journal Article
Keywords: Transforming growth factor-β; Corneal stroma; Scarring; Molecular mechanism
From: Chinese Journal of Experimental Ophthalmology 2015;33(5):466-469
CountryChina
Language:Chinese
Abstract: Transforming growth factor-β (TGF-β) plays a key role during corneal stroma scarring.It is a critical regulator in abnormal deposition of extracellular matrix (ECM) and construction of collagen fibers.TGF-β is a family cytokines secreted by a variety of cells.It has multiple effects only when it is activated.The major signaling pathway of TGF-β is Smad,which is activated by the binding of TGF-β and its receptors.TGF-β stimulates the synthesis and secretion of collagen and proteoglycan,which results in disbalance of synthesis and degradation of ECM.The mechanism of TGF-β on promoting corneal fibrosis includes upregulating connective tissue growth factor (CTGF),downregulating keratin sulfate proteoglycans(KSPGs) and inhibiting the degradation of ECM by regulating matrix metalloproteinases(MMPs).Recently,TGF-β has been a promoting growth factor of scar-free wound healing because of its extensive biological effects.This review summarized biological characteristics of TGF-β,its receptors and Smads signal pathway and the molecular mechanism that accelerates corneal stroma scarring.