Role of placental growth factor in neovascularage-related macular degeneration
10.3980/j.issn.1672-5123.2015.5.13
- VernacularTitle:PlGF在湿性黄斑变性中的作用探讨
- Author:
Rui-Xin, WANG
;
Guo-Xing, XU
- Publication Type:Journal Article
- Keywords:
placental growth factor;
neovascularage-related macular degeneration;
pathogenesis;
Aflibercept;
Conbercept
- From:
International Eye Science
2015;(5):796-798
- CountryChina
- Language:Chinese
-
Abstract:
? Choroidal neovascularization is the primary pathogenesis of neovascularage - related macular degeneration ( nAMD ) , and the role of vascular endothelial growth factor ( VEGF ) in neovascularization has been widely recognized. Currently, drugs target different targets of VEGF have been widely used in the treatment of nAMD. As a subtype of VEGF, placental growth factor ( PlGF) has synergistic effects with VEGF-A on promoting angiogenesis, stimulating the migration of endothelial cell proliferation and mediating immune inflammatory response. There is no expression of PlGF in mature blood vessels so PlGF hashigh specificity. ln this paper, the role of PlGF in the pathogenesis and treatment of nAMD is reviewed.
