Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms
10.3980/j.issn.1672-5123.2015.5.24
- VernacularTitle:原发性闭角型青光眼易感性与GSTM1和GSTT1基因多态性的关系
- Author:
Li-Dan, LUO
- Publication Type:Journal Article
- Keywords:
primary angle-closure glaucoma;
genetic polymorphism;
glutathione S-transgerase
- From:
International Eye Science
2015;(5):836-838
- CountryChina
- Language:Chinese
-
Abstract:
?AlM:To investigate the relationship of susceptibility of primary angle- closure glaucoma with glutathione S-transferase T1 ( GSTT1 ) and M1 ( GSTM1 ) polymorphisms.
? METHODS: Totally, 300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control group. The observation group were divided into chronic and acute primary angle-closure glaucoma groups, then multiplex PCR technology was used to detect the genetic polymorphisms of GSTM1 and GSTT1.
?RESULTS:The distribution frequencies of GSTT1-null genotype were 54. 3%, while it was 54. 0% in the control group, statistically no significance between control group and observation group (χ2 = 0. 053, P > 0. 05 ) ; The frequency GSTT1 - null genotype in chronic group of primary angle-closure glaucoma was 54. 9%, while it was 48. 6% in the acute group of primary angle - closure glaucoma, statistically no significance between control group and acute group(χ2=0. 064, P>0. 05), and chronic group (χ2=0. 037, P>0. 05); The distribution frequencies of GSTM1-null genotype was 59. 0%, while it was 55. 7%in the control group, statistically no significance between control group and observation group (χ2=0. 013, P>0. 05);The distribution frequencies of GSTM1-null genotype was 62. 3% and 58. 1% in acute and chronic group of primary angle - closure glaucoma patients respectively. Acute group of primary angle - closure glaucoma has no significant compared with control group (χ2 = 0. 005, P>0. 05), Chronic group of primary angle-closure glaucoma had no significant compared with control group (χ2 = 0. 047, P>0. 05).
?CONCLUSlON:No statistic significance relationship is found between primary angle-closure glaucom patients and the null genotypes of GSTM1 and GSTT1 susceptibility.
