HLA-DR Antigens and HLA-B: DR Haplotypes in Koreans.
- Author:
Se Jong KIM
1
;
In Hong CHOI
;
Joo Duek KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: HLA-DR antigens; HLA-B:DR haplotypes; Korean
- MeSH: Gene Frequency; HLA Antigens/analysis*; HLA-B Antigens; HLA-DR Antigens; Haploidy; Histocompatibility Antigens Class II/analysis*; Human; Korea; Mongoloid Race*
- From:Yonsei Medical Journal 1983;24(1):33-37
- CountryRepublic of Korea
- Language:English
- Abstract: HLA-DR antigen and gene frequencies were studied in 150 unrelated Koreans in Seoul. HLA-DR4 was the most common DR specificity encountered and HLA-DR1 and -DR3 occurred with the lowest frequencies. The frequency of HLA-DR blank allele was 27.1%. HLA-B:DR haplotypes involving positive delta values differing significantly from zero were DR1:B7, DR2:Bw22, DR3:B17, DR5:Bw35, DRw6:B17, DR7:B12, DR7:B13, and DRw8:Bw16. The supertypic groups (MT1, MT2 and MT3) differ somewhat in frequencies from Other populations. These findings suggested that the Korean population, while having many similarities in HLA-DR antigen frequencies with those of neighboring Orientals, has not only different features in the distribution of HLA-DR antigens but also has unique HLA-B:DR haplotypes.
