Consistency analysis of Keratograph and traditional methods to evaluate tear film function
10.3980/j.issn.1672-5123.2015.5.27
- VernacularTitle:Keratograph眼表综合分析仪与传统方法对泪膜功能评价的一致性分析
- Author:
Pei-Yang, SHEN
;
Hai-Bo, CHEN
;
Hong-Shan, LIU
;
Ming-Bing, ZENG
;
Xiong-Gao, HUANG
;
Jian-Qiang, XING
;
Xing-Wu, ZHONG
- Publication Type:Journal Article
- Keywords:
tear film stability;
Keratograph;
noninvasive tear film break-up time;
fluorescein tear film break-up time
- From:
International Eye Science
2015;(5):846-849
- CountryChina
- Language:Chinese
-
Abstract:
?AlM: To investigate repeatability and accuracy of a latest Keratograph for evaluating the tear film stability and to compare its measurements with that of traditional examination methods.
?METHODS: The results of noninvasive tear film break-up time ( Nl-BUT ) including the first tear film break-up time ( BUT-f ) and the average tear film break-up time ( BUT - ave ) were measured by Keratograph. The repeatability of the measurements was evaluated by coefficient of variation ( CV ) and intraclass correlation coefficient ( lCC) . Wilcoxon Signed-Rank test was used to compare Nl-BUT with fluorescein tear film break-up time ( FBUT) to confirm the correlation between Nl-BUT and FBUT, Schirmer l test values. Bland-Altman analysis was used to evaluate consistency.
?RESULTS: The study recruited 48 subjects ( 48 eyes ) (mean age 38. 7±15. 2 years). The CV and lCC of BUT-f were respectively 12. 6% and 0. 95, those of BUT-ave were 9. 8% and 0. 96. The value of BUT-f was lower than that of FBUT. The difference had statistical significance ( 6. 16±2. 46s vs 7. 46±1. 92s, P<0. 01). There was significant positive correlation between Nl-BUT and FBUT, Schirmer l test values ( P< 0. 01 ). The scope of 95% limits of agreement (LoA) was 4. 46s in BUT-f and FBUT, while the scope of LoA was 3. 64s in BUT-ave and FBUT.
?CONCLUSlON: Keratograph can provide Nl-BUT data that has a better repeatability and reliability, which has great application prospects in diagnosis and treatment of dry eye and refractive corneal surgery.
