PDT combined with intravitreal injection of ranibizumab treatment for age - related macular degeneration with CNV
10.3980/j.issn.1672-5123.2015.4.24
- VernacularTitle:PDT联合 ranibizumab玻璃体腔注射治疗年龄相关性黄斑变性合并CNV
- Author:
Xue-Yan, YANG
;
Jin-Xian, HE
;
Xian-Jun, LIANG
;
Sheng, ZENG
- Publication Type:Journal Article
- Keywords:
PDT treatment;
ranibizumab;
age-related macular degeneration;
choroidal neovascularization
- From:
International Eye Science
2015;(4):659-661
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the curative effect of PDT combined with intravitreal injection of ranibizumab treatment for age-related macular degeneration with choroidal neovascularization ( CNV) .
METHODS:In accordance with the inclusion criteria, by indocyanine green choroidalangiography ( ICGA ) and optical coherence tomography ( OCT ) examination confirmed the diagnosis of macular CNV in 27 patients (27 eyes), treated with PDT 3 ~ 7d professional intravitreal injection of ranibizumab. At 1, 3, 6mo after treatment, the results of best corrected visual acuity (BCVA), FFA, ICGA, OCT examination and complications were observed.
RESULTS: The BCVA improved in 17 eyes ( 63%) , stable in 6 eyes ( 22%) , and decreased in 4 eyes ( 15%) . Before treatment, the average leakage area was 1 005. 69±105. 47μm, it were 875. 54 ± 103. 27μm, and 423. 37 ±79.68μm at 1 and 3mo after treatment, there were significant differences compared with before treatment ( P<0. 01). Average central macular thickness of retina before treatment was 485. 58±122. 59μm, and 398. 84±105. 32μm, 297. 74±89. 18μ m at 1 and 3mo after treatment, there were significant differences compared with before treatment( P<0. 01).
CONCLUSION: The method that PDT closed CNV combined with intravitreal injection of ranibizumab can effectively block angiogenesis recurrence, reduce the number of PDT treatment again and complications, improve the therapeutic effect.
