Research progress of α-crystaIIin in regeneration of optic nerve injury
10.3980/j.issn.1672-5123.2015.3.18
- VernacularTitle:α晶体蛋白在视神经损伤后再生中的作用研究进展
- Author:
Yun-Ting, LI
;
Xia, CAO
;
Lin-Kun, MA
- Publication Type:Journal Article
- Keywords:
α-crystallin;
optic nerve injury/regeneration;
retinal ganglion cells
- From:
International Eye Science
2015;(3):448-450
- CountryChina
- Language:Chinese
-
Abstract:
·α-crystallin is the predominant structural protein in the lens.lt is a member of small heat shock proteins ( sHSPs) which has the common functions of HSPs.lt also has anti-apoptotic activity etc.Recently, it has been proved to combine with the cellular membrane of retinal ganglion cells ( RGCs ) to enhance the survival of RGCs and the regeneration of axons, thereby partly restore visual function.But we haven’t come to a unified conclusion of the mechanism.This review is focused on structure and functions of α-crystallin, the protection function and mechanism of α-crystallin towards RGCs after the optic nerve injury.
