Research the correIation of vascuIar endotheIiaI growth factor and fibrosis -reIated cytokines in proIiferative diabetic retinopathy
10.3980/j.issn.1672-5123.2015.3.20
- VernacularTitle:PDR 中血管内皮生长因子与纤维化相关细胞因子的相关性
- Author:
Mei-Qi, WEI
;
Xiao-Long, CHEN
;
Xue-Mei, FENG
;
Hong-Wei, YANG
;
Chun-Liu, GAI
- Publication Type:Journal Article
- Keywords:
proliferative diabetic retinopathy;
vascular endothelial growth factor;
cytokine
- From:
International Eye Science
2015;(3):454-458
- CountryChina
- Language:Chinese
-
Abstract:
· Vascular endothelial growth factor is indispensable inducing factor in retinalangiogenesis. After the retinal neovascularization of proliferative diabetic retinopathy ( PDR ) patients, it can cause fibrovascular membrane formation, epiretinal membrane fibrosis increased, resulting in traction retinal detachment with further aggravate the condition. The recent research suggests that cytokines promote fibroblast proliferation, movement, adhesion, and secretion of extracellular matrix functions in the diabetic state of the environment changes to profibrogenic state, resulting in the accumulation and fibrosis of extracellular matrix. This paper reviewed the status quo of the correlation between vascular endothelial growth factor and fibrosis-related cytokine.
