Research progress of SlRT1 as a target for the treatment of age - related retinal disease
10.3980/j.issn.1672-5123.2015.2.12
- VernacularTitle:SlRT1作为靶点治疗年龄相关性视网膜病变的研究进展
- Author:
Yan, ZHANG
;
Bo-Yu, LU
;
Hui-Min, ZHANG
;
Shi-Hui, WEI
- Publication Type:Journal Article
- Keywords:
silent information regulator protein 1;
neuro- protective effect;
research progression;
age -related retinal disease
- From:
International Eye Science
2015;(2):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator protein 1 (SlRT1) is one of the sirtuins and belongs to histone deacetyase. lts activity depends on nicotinamide adenine dinucleotide ( NAD+) and is regulated by NAD+. Experimental and clinical studies have shown the neuro-protective effect of SlRT1 in the pathogenesis of age-related eye diseases. ln this review, the relationship between SlRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SlRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.
