Oxidative stress - mitochondrial dysfunction and the relationship with retinal ganglion cell apoptosis
10.3980/j.issn.1672-5123.2015.2.13
- VernacularTitle:氧化应激-线粒体功能异常与视网膜神经节细胞凋亡的关系
- Author:
Qian, HAN
;
Ling, YU
- Publication Type:Journal Article
- Keywords:
mitochondrial dysfunction;
oxidative stress;
glaucoma;
retina ganglion cell;
apoptosis
- From:
International Eye Science
2015;(2):238-241
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria play an important role in energy ( ATP ) production through oxidative phosphorylation pathway and the regulation of cell death by apoptosis. Mitochondrial dysfunction has been implicated in the pathophysiology of a number of neurodegenerative diseases. Glaucoma as a neurodegenerative disorder, mitochondrial oxidative stress in the pathogenesis of glaucoma and the damage of RGCs has received close attention in recent years. ln this article, we reviewed the current evidences and recent advances in the relationship between mitochondrial oxidative stress and the RGCs apoptosis.
