Security research of cardiac death donation corneas used as penetrating keratoplasty grafts
10.3980/j.issn.1672-5123.2015.2.36
- VernacularTitle:心脏死亡后捐献角膜用作穿透性角膜移植术供体的安全性研究
- Author:
Jing, XU
;
Hong, ZHANG
;
Ji-Pin, JIANG
;
Ling-Juan, XU
;
Jian-Fang, DU
;
Min, CHEN
;
Jian-Qing, MA
;
Gui-Gang, LI
- Publication Type:Journal Article
- Keywords:
cardiac death donation;
penetrating keratoplasty;
corneal endothelial cell;
best corrected visual acuity
- From:
International Eye Science
2015;(2):317-319
- CountryChina
- Language:Chinese
-
Abstract:
To test the safety of using cardiac death donation ( DCD ) corneas for penetrating keratoplasty surgery graft.METHODS:ln chronological order, suing DCD corneas penetrating keratoplasty, corneal endothelial cell density and best corrected visual acuity ( BCVA) were tested 3~4mo after surgery.RESULTS:A total of 14 cases of DCD while 26 corneas were included in this study. Donors age ranged 0. 5 ~61 years, averagely 38. 3 ± 15. 6 years. Causes of death included that 9 cases of traumatic brain injury, 2 cases myocardial infarction, 2 cases brain stem hemorrhage, 1 case of respiratory and circulatory failure. All 26 patients underwent penetrating keratoplasty, no rejection occurred and all grafts were transparent 3 ~ 4mo after surgery. Three to four months after surgery, corneal endothelial cell density ranged 794 ~ 4 347/mm2 , averaged 2 305 ± 827/mm2 , within which was only one case was lower than 1000/mm2 (3. 8%), while 9 cases ranged from 1000 ~ 2000/mm2 (34. 6%), 16 cases were higher than 2000/mm2 (61. 5%). The age of all the 26 receipts were from 20~80 years, mean 40. 7±17. 1 years. BCVA before surgery was light perception positive to 0. 08, with an average 0. 027±0. 024. Three to four months after surgery, BCVA were 0. 2~0. 8, with an average 0. 52± 0. 182 in contrast (t=3. 96, P<0. 001).CONCLUSlON:DCD donated corneas could be used for penetrating keratoplasty graft with high security.
