In Vitro Antimicrobial Activity of Cefroxadine, an Oral Cephalosporin, Against Major Clinical Isolates.
- Author:
Jongyoun YI
1
;
Jae Kyu LEE
;
Eui Chong KIM
Author Information
1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. euichong@plaza.snu.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Cefroxadine;
Antibiotic susceptibility;
Cephalosporin
- MeSH:
Agar;
Citrobacter freundii;
Cloaca;
Enterobacter cloacae;
Enterobacteriaceae;
Escherichia coli;
Gram-Positive Bacteria;
Haemophilus influenzae;
Influenza, Human;
Klebsiella pneumoniae;
Korea;
Mirabilis;
Moraxella (Branhamella) catarrhalis;
Pneumonia;
Proteus mirabilis;
Serratia marcescens;
Staphylococcus;
Staphylococcus aureus;
Staphylococcus epidermidis;
Streptococcus pneumoniae
- From:Korean Journal of Clinical Microbiology
2003;6(1):37-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cefroxadine is an oral first-generation cephalosporin, which has been used for several years. But, the susceptibility data of cefroxadine were rarely reported in Korea. The current study attempted to determine the antibacterial activity of cefroxadine against the major clinical isolates. METHODS: According to the NCCLS recommendations, antibacterial activities of cefroxadine were measured against total 500 major clinical isolates. MICs were determined by the agar dilution method, a series of doubling dilutions from 128 to 0.03 /mL, on Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Serratia marcescens, Proteus mirabilis, and Staphylococcus spp. In case of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis, broth microdilution method, a series of doubling dilutions from 16 to 0.015 /mL, was performed. RESULTS: Cefroxadine had variable activity against Enterobacteriaceae. MIC cumulative curves showed that cefroxadine had relatively low MIC distributions against E. coli, K. pneumoniae and P. mirabilis, showing MIC50 were 4, 4, and 8 /mL, respectively. Against E. cloacae, C. freundii, and S. marcescens, cefroxadine 's MIC50 values ranged from 128 to >128 /mL. For clinical isolates of methicillin-susceptible Staphylococcus aureus and methicillin-susceptible Staphylococcus epidermidis, cefroxadine had MIC90 values were 4 /mL and 8 /mL, respectively. Cefroxadine had MIC50 values of 1 /mL and >16 /mL for penicillin-susceptible and penicillin-not-susceptible strains of S. pneumoniae, respectively. Cefroxadine had MIC50 values of 8 /mL and 4 /mL against H. influenzae and M. catarrhalis, respectively. CONCLUSION: Cefroxadine had good activity against gram-positive bacteria, except penicillin-resistant S. pneumoniae, and showed moderate antimicrobial activity against M. catarrhalis, E. coli, P. mirabilis, and K. pneumonaie. Cefroxadine had variable activity against Enterobacteriaceae other than the above-mentioned species.
