Antibiogram of Escherichia coli and Klebsiella spp. Detected by Vitek ESBL Test.
- Author:
Eun Hae CHO
1
;
Nam Yong LEE
Author Information
1. Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mrmicro@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Vitel GNS 433 Card;
ESBL;
Cefepime;
Cefoxitin;
Imipenem
- MeSH:
Aminoglycosides;
Anti-Infective Agents;
Cefoxitin;
Cephamycins;
Escherichia coli*;
Escherichia*;
Fluoroquinolones;
Humans;
Imipenem;
Klebsiella*;
Korea;
Microbial Sensitivity Tests*;
Pneumonia;
Prevalence;
Seoul
- From:Korean Journal of Clinical Microbiology
2003;6(1):47-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Extended-spectrum beta -lactamase (ESBL) producing Escherichia coli and Klebsiella spp. isolates are clinically resistant to all the beta -lactams except carapenems and cephamycins. This study was to determine the prevalence of ESBL producing E. coli and Klebsiella spp. and the rates and trends of resistance to extended-spectrum beta -lactams and other antimicrobial agents in ESBL producing E. coli and Klebsiella spp.. METHODS: During the periods of 2002, a total 2,551 clinical isolates of E. coli & Klebsiella spp. were collected from patients of the Samsung medical center, Seoul, Korea. Antimicrobial susceptibility test and determination of ESBL production were performed by Vitek GNS-433 card. RESULTS: 151/1,594 (9.5%) of E. coli isolates, 128/896 (14.3%) of K. pneumoniae isolates and 11/61 (18.0%) of K. oxytica were ESBL producing strains. Resistance to cefoxitin and cefepime were 2.4% and 13.4% in ESBL producing isolates. Imipenem had excellent activity against E .coli and Klebsiella spp. (100% susceptible). CONCLUSION: In this study, ESBL-producing E. coli and Klebsiella spp were more resistant to beta -lactams including cefepime than ESBL non-producing E. coli and Klebsiella spp.. ESBL producing E. coli and Klebsiella spp. showed a high level of co-resistance with aminoglycosides and fluoroquinolones. Imipenem showed the highest level of activity against E. coli and Klebsiella spp..
