New research progress of microRNAs in retinoblastoma
10.3980/j.issn.1672-5123.2014.11.21
- VernacularTitle:MicroRNAs在视网膜母细胞瘤的研究新进展
- Author:
Jing, ZENG
;
Rui-Xue, TANG
;
Rong-Quan, HE
;
Gang, CHEN
- Publication Type:Journal Article
- Keywords:
microRNAs;
retinoblastoma;
oncogenes;
tumor suppressor gene
- From:
International Eye Science
2014;(11):1995-1998
- CountryChina
- Language:Chinese
-
Abstract:
Retinoblastoma(RB)is the most common intraocular malignancy of children with extremely poor prognosis. MicroRNAs are small non-coding single-stranded RNAs in eukaryotic cells, which regulate the expression of gene by mRNA degradation or translation inhibition. MicroRNAs, acting as oncogenes or tumor suppressor genes, are associated with the occurrence and development of RB directly, which is vital for the early diagnosis and clinical targeted therapy of RB. This review summarized the expression of microRNAs in RB and the related mechanism.
