Relationship between vimentin and glucocorticoid-induced cataract
10.3980/j.issn.1672-5123.2014.11.16
- VernacularTitle:波形蛋白与糖皮质激素性白内障的关系
- Author:
Jia-Jia, GE
;
Sheng, SU
;
Ping, LIU
- Publication Type:Journal Article
- Keywords:
vimentin;
glucocorticoid;
glucocorticoid-induced cataract;
lens
- From:
International Eye Science
2014;(11):1975-1977
- CountryChina
- Language:Chinese
-
Abstract:
Long-term use of systemic or topical glucocorticoid can cause posterior subcapsular opacities ( PSO ) , named glucocorticoid-induced cataract ( GIC ) . There are many hypotheses on the pathogenesis of GIC. However, no one has well explained the formation of PSO, which leads to no effective approaches in the prevention and/or treatment. A new opinion is that hormones might affect lens epithelial cells through GR - mediated vimentin changes, which eventually result in the formation of GIC. Therefore, the association between vimentin and lens epithelial cell proliferation and differentiation, maybe a new direction for further studies in the pathogenesis of GIC.
