Expression of matrix metrallproteinase-2 in human tears fluid after LASlK
10.3980/j.issn.1672-5123.2014.12.34
- VernacularTitle:准分子激光角膜磨镶术后患者泪液中基质金属蛋白酶-2的表达
- Author:
Ai-Wei, CHEN
;
Hong-Pei, JI
;
Wei-Wei, ZHANG
;
Hong, GU
;
Zhi-Ling, ZHANG
;
Ju-Qin, FU
- Publication Type:Journal Article
- Keywords:
laser in situ keratomileusis;
matrix metalloproteinase-2;
human;
tear fluid
- From:
International Eye Science
2014;(12):2229-2231
- CountryChina
- Language:Chinese
-
Abstract:
AlM: To monitor long - term changes of matrix metalloproteinase-2 ( MMP-2 ) in human tears fluid after laser in situ keratomileusis ( LASlK) .
METHODS: Thirty - two myopia cases ( 64 eyes ) underwent uneventful LASlK were enrolled in the study. Tear fluid were collected and MMP-2 expression was analyzed by Western - bolt assay preoperatively and postoperatively on 15d, at 1, 3mo, and 1a.
RESULTS:LASlK increased the concentration of MMP-2 in human tear fluid. At 15d postoperatively, the magnitude of MMP-2 was 1. 4 times that of preoperative, thereafter subsided, but didn't return to preoperative level by 3mo ( P < 0. 05 ). Up to 1a after surgery, the concentration of MMP-2 almost recovered (P>0. 05).
CONCLUSlON: MMP- 2 is significantly expressed in human tear fluid after LASlK, then subsided with time, but didn't return to preoperative level by 3mo and almost recovered up to 1a, indicating wound healing of LASlK would continue up at least 3mo after surgery and almost recovered 1a postoperatively.
