Efficacy of limbal stem cell transplantation combined with mitomycin C in pterygium patients with T2 DM
10.3980/j.issn.1672-5123.2015.1.51
- VernacularTitle:自体角膜缘干细胞移植联合丝裂霉素C在合并T2 DM的翼状胬肉患者中的应用效果
- Author:
Ya-Dan, YAO
;
Xin, XIE
- Publication Type:Journal Article
- Keywords:
limbal stem cell transplantation;
mitomycin C;
type 2 diabetes mellitus;
pterygium
- From:
International Eye Science
2015;(1):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Abstract?AlM:To investigate effect and safety of the limbal stem cell transplantation combined with low concentrations of mitomycin C for pterygium patients with type 2 diabetes mellitus (T2DM).? METHODS: Eighty patients of 96 pterygium eyes admitted to hospital were divided into groups of high concentration, low concentration group and the control group, and 3 groups were given pterygium excision combined with limbal stem cell transplantation. The high concentration group, the low concentration groups were given prior to stem cell transplantation 0. 2, 0. 1mg/mL mitomycin C coverage. The cure rate and recurrence rate in three groups of patients, as well as visual acuity before and after treatment were compared.?RESULTS: Three groups patients' visual acuity were significantly improved after treatment (P<0. 05), there was no significant difference before treatment in visual acuity (P>0. 05);epithelial healing time of high concentration group was significantly higher than low concentration group and the control group (P<0. 05), there was no significant difference between low concentration and control groups of epithelial healing time (P>0. 05); cure rates of low concentration group was higher than high dose group, the recurrence rate in low concentration group was lower than the high dose group.? CONCLUSlON: Pterygium excision combined with limbal stem cell transplantation has significant efficacy for pterygium, and mitomycin C can effectively reduce the relapse rate, but for the patients with T2DM concentration of mitomycin C should be reduced.
