Recent advance in P2Y2 receptor agonist for the treatment of dry eye

VernacularTitle:P2Y2受体激动剂治疗干眼的研究进展
Author: Yuqiu, ZHANG
Publication Type:Journal Article
Keywords: P2Y2 receptor agonist; Diquafosol tetrasodium; Dry eye/ therapy
From: Chinese Journal of Experimental Ophthalmology 2014;32(9):856-859
CountryChina
Language:Chinese
Abstract: Dry eye is a group of multifactor-induced ocular surface symptoms.The conventional therapy for dry eye is to increase the tear passively,such as topical administration of artificial tears eye drops and blockage of lacrimal punctum.However,with a better understanding of pathogenesis of dry eye,it is thought that an ideal method for dry eye is to promote the secretion of tear.Studies showed that P2Y2 receptor agonists can promote the lacrimal gland to secrete tear actively.Up to now,multiple synthetic P2Y2 receptor agonist mimics have been studied,and these studies confirmed that these drugs can improve the secretion of not only water-like tear but also mucoprotein,which can alleviate symptoms in patients with dry eye.In addition,good safety also is clarified by clinical trial of phase Ⅰ.This review briefly summarize the researches on active mechanism,clinical efficacy and applying prospect of P2Y2 receptor agonist for the treatment of dry eye.