Prospects of corneal xenotransplantation
10.3760/cma.j.issn.2095-0160.2014.09.017
- VernacularTitle:异种角膜移植前景展望
- Author:
Huijuan, AN
;
Wen, JIANG
- Publication Type:Journal Article
- Keywords:
Cornea;
Xenotransplantation;
Rejection;
Porcine
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(9):848-851
- CountryChina
- Language:Chinese
-
Abstract:
Donor shortage in corneal transplantation is an emerging issue.Recent studies showed that compared with other organ transplantation,the rejection of corneal transplantation is weak due to the immune privilege,and the anatomical and biomechanical properties of human corneas are similar to pig corneas,so genetically engineered pigs have great potentials as a new source for clinical transplantation.This review discussed current knowledge of the pathogenesis of the rejection mechanism,recent advances in gene engineering pig,and feasibility of porcine xenocorneal graft.
