Research progress on racemization of crystallins and pathogenesis of cataract
10.3760/cma.j.issn.2095-0160.2014.06.018
- VernacularTitle:晶状体蛋白的外消旋化及其在白内障发病机制中的研究进展
- Author:
Keke, ZHANG
;
Xiangjia, ZHU
- Publication Type:Journal Article
- Keywords:
Racemization;
Crystallin;
Cataract;
Post-translational modification
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(6):563-567
- CountryChina
- Language:Chinese
-
Abstract:
Racemization is probably the most abundant post-translational modification (PTM) in aged lens.According to previous studies,L-amino acid in α,β and γ crystallins are tend to transfer into D-amino acid with aging,leading to a series of age-related changes in the structure,metabolism and function of lens.Aggregated highmolecular-weight proteins gradually accumulate in both nuclear and cortex region,which will have a negative effect on the function of crystallins and finally lead to capacity of lens.Moreover,it is likely that racemization of crystallins eventually leads to cataract formation and development as well.The material effect and mechanism of racemization changes in human age-related lens still requires further research.
