Study progress in the relationship of CYP1B1 gene mutation with primary open angle glaucoma
10.3760/cma.j.issn.2095-0160.2014.07.018
- VernacularTitle:CYP1B1基因突变与原发性开角型青光眼发病关系的研究进展
- Author:
Yihong, HUANG
- Publication Type:Journal Article
- Keywords:
Glaucoma,open-angle/genetics;
DNA mutation;
Genetic predisposition to disease
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(7):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Primary glaucoma is a group of blinding eye diseases,including of primary open angle glaucoma (POAG),primary angle-closure glaucoma (PACG) and primary congenital glaucoma (PCG).It is thought that the pathogenesis of primary glaucoma is a comprehensive action of genetic factor,environment factor and life style,and the genetic factor plays an important role.CYP1B1 gene was firstly identified as a causal gene for PCG in 1997.After that,thousands of reports on the pathogenesis of POAG focused on CYP1B1 gene mutation.With the developing of research,researches found that CYP1B1 gene to be one of the candidate genes of POAG.The structure and function of CYP1B1 gene,the relationship between CYP1B1 and POAG were reviewed.
