Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease.
- Author:
Kang Yoon LEE
1
;
Young Min LEE
;
Je Min PARK
;
Byung Dae LEE
;
Eun Soo MOON
;
Hee Jeong JEONG
;
Young In CHUNG
;
Ji Hoon KIM
Author Information
1. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- Publication Type:Original Article
- Keywords:
Late life major depression;
Cortical thickness;
Magnetic resonance imaging
- MeSH:
Busan;
Depression*;
Humans;
Korea;
Magnetic Resonance Imaging;
Memory;
Vascular Diseases*
- From:Journal of Korean Geriatric Psychiatry
2015;19(2):97-100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). METHODS: Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal comparison subjects : n=26) underwent 3-tesla MRI. RESULTS: Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. CONCLUSION: Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.
