Research progress of choline and dopamine signaling pathways related to myopia
10.3760/cma.j.issn.2095-0160.2014.05.015
- VernacularTitle:近视相关胆碱与多巴胺信号通路研究进展
- Author:
Fang, SHA
;
Jianfeng, WU
- Publication Type:Journal Article
- Keywords:
Myopia;
Pathogenesis mechanism;
Acetylcholine receptor;
Dopamine;
Retinal circadian rhythm
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(5):457-461
- CountryChina
- Language:Chinese
-
Abstract:
It was confirmed that acetylcholine signaling pathway and dopamine signaling pathway play critical roles in refractive development.Many evidences have supported that acetylcholine and its receptor antagonists were closely related to the formation of experimental myopia.Retinal dopamine signaling could exert a significant influence on refractive development,and its upregulation induced by light comprises an important component of the retinal clock network;meanwhile,the retinal dopamine signaling could also participate in the regulation of retinal circadian rhythms.The role of intrinsic retinal circadian rhythms in the developing process of myopia is gaining increasing attention.Moreover,it was also found that both acetylcholine and dopamine signaling pathways influence the development of myopia.Therefore,the present paper summarizes the two signaling pathways in the mechanisms of regulating myopia process,which provides an insight into the pathogenesis of myopia and clinical ideas for the effective prevention and treatment of myopia.
