Research progress in Cre recombinase mouse models in ophthalmology
10.3760/cma.j.issn.2095-0160.2014.05.018
- VernacularTitle:Cre重组酶眼部动物模型研究进展
- Author:
Yuzhi, DING
- Publication Type:Journal Article
- Keywords:
Transgenic mouse;
Animal model;
Cre;
Eye
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(5):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Cre/LoxP site specific recombinase system is an effective tool for gene recombination in the body to produce specific gene deletion or inversion.The study of gene function is the experimental basis for the development of experimental animal models.Study the Cre/LoxP system,compare the different function characteristics of mouse models for Cre recombinase system in the research of ophthalmology,epecially in the tissue of retina,such as retinal pigment epithelium (RPE) cells,Müller cells and photoreceptor cells,get the Cre transgenic mouse model to establish proper experimental animal models of ophthalmology will lay a solid foundation for the research of the lack of single gene for a particular organization study.Here,the research progress of Cre/LoxP system,the Cre transgenic mouse models and eye specific Cre recombinant enzyme model mice will be summarized.
