Retinal lesions and potential confounders in mouse models
10.3760/cma.j.issn.2095-0160.2014.04.001
- VernacularTitle:应用眼底病小鼠模型须考虑的因素
- Author:
Jingsheng, TUO
;
Chi-Chao, CHAN
- Publication Type:Journal Article
- Keywords:
Model,animal;
Mouse,mutant strain;
Retina disease;
Retinal degeneration/genetics;
Phenotype
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(4):289-291
- CountryChina
- Language:Chinese
-
Abstract:
During the application of spontaneous or genetically engineered mouse models for retinal diseases,some phenotypes of the models might not be related to the gene (s) of interest or intentional manipulation.This problem often arises from founder effect of inbreed mouse strains.The most impact experiences in vision research community are mouse models incorporated with mutations in Crb1 (rd8),phosphodiesterase 6 beta (Pde6b) (rd1),Gnat2 and RPE65 genes.This paper reviewed the most relevant articles on this matter.We encourage that vision researchers who apply or develop mouse lines to study retinal diseases should carefully track and check the genetic background of their stains and/or choose proper controls in the study design.
