Research progress in chemokine receptor 3 and its ligands in ophthalmology
10.3760/cma.j.issn.2095-0160.2014.03.018
- VernacularTitle:趋化因子受体3及其配体在眼部疾病中的作用
- Author:
Lu, LI
- Publication Type:Journal Article
- Keywords:
Chemokine receptor 3;
Eotaxin;
Choroidal noevascularization;
Ophthalmology
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(3):270-273
- CountryChina
- Language:Chinese
-
Abstract:
Chemokine receptor 3 (CCR3) and its ligands eotaxin are inflammatory factors,and they were thought to be related to asthma and allergic diseases before.Recent studies showed that CCR3 plays significant roles in many eye diseases,such as choroidal noevascularization (CNV),allergic cunjunctivititis,age-related macular degeneration (AMD),central retinal vein occlusion and retinal degeneration etc.The biological function study suggested that CCR3 and eotaxin participate in not only promoting the transportation of eosinophilic granulocyte and mastocyte but also inflammatory response.To understand the roles of CCR3 and eotaxin in eye diseases has a very important significance for the recognition and treatment of eye diseases.The structure and function of CCR3 and its ligands,and the relationship between CCR3 and some eye diseases were reviewed.
