Study on the thionylation to synthesize thiosalicylanilide derrivatives with antifungal and antibacterial activities
- Author:
Truong -- Phuong
- Publication Type:Journal Article
- Keywords:
Thiosalicylanilide
- MeSH:
Anti-Bacterial Agents;
Plants, medicinal
- From:Pharmaceutical Journal
2005;354(10):8-12
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Condensation of salicylic acid with anilines made salicylanilid derivatives. From salicylanilids, 3-phenyl-2H-1, 3-benzoxazin-2, 4(3H)-dion derivatives were created by same circle reaction. Thionylation reaction 3-phenyl-2H-1, 3-benzoxazin-2,4(3H)-dion in dioxan solvent had good result. Products of thionylation created thiosalicylanilides after circle opened hydrolysis. Clearness of thiosalicylanilides was determined by thin layer chromatography and their structure was determined by UV, IR.H1 MNR. Antibacterial effect of synthetic products, especially Streptococcus feacalis E.coli was higher than control substance as salicylanilid. Antifungal effect of Bromo and clorothiosalicylanilide derivatives was stronger than other derivatives
