Relationship between carotid plaque neovascularization and coronary heart disease by using contrast-enhanced ultrasound
10.3877/cma.j.issn.1672-6448.2013.09.012
- VernacularTitle:超声造影对颈动脉斑块新生血管密度与冠状动脉粥样硬化性心脏病相关性的评价
- Author:
Ying, ZHU
;
You-bin, DENG
;
Ya-ni, LIU
;
Xiao-jun, BI
;
Hao-yi, YANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Contrast media;
Acute coronary syndrome;
Atherosclerosis
- From:
Chinese Journal of Medical Ultrasound (Electronic Edition)
2013;(9):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between carotid plaque neovascularization and coronary heart disease using contrast-enhanced ultrasound. Methods We studied carotid plaques in 312 patients with coronary artery disease by contrast-enhanced ultrasound [51 patients with acute coronary syndrome (ACS) and 261 patients with stable coronary artery disease (sCAD) ]. We analyzed sonographic features of each plaque, including the enhancement intensity of plaque (A value), the ratio of plaque to carotid artery lumen in enhancement intensity (Ratio), plaque thickness and plaque echo (soft plaque, hard plaque, mixed plaque, calcified plaque). Results The average thickness of plaque in patients with ACS and in patients with sCAD had no significant difference in statistics [(2.6±0.4) mm vs (2.9±0.8) mm, t=-1.903, P=0.058) ]. The group with ACS:soft plaque 43 (84.3%, 43/51), mixed plaque 8 (15.7%,8/51), no hard plaque and calcified plaque. And the group with sCAD:soft plaque 174 (66.7%,174/261), hard plaque 19 (7.3%,19/261), mixed plaques 16 (6.1%,16/261), calcified plaque 52 (19.9%,52/261). The percentage of soft plaque in the acute coronary syndrome group was significantly higher than that in stable coronary artery disease group (χ2=6.274,P=0.012). The A value and Ratio in patients with ACS were prominently larger than those in patients with sCAD [ (11.3±3.2) vs (8.9±3.3) dB, t=7.150,P<0.01;0.6±0.2 vs 0.4±0.2, t=7.419,P<0.01].Conclusion Carotid artery plaque neovascularization density was significantly higher in patients with ACS than that in patients with sCAD by using contrast-enhanced ultrasound, revealing that the neovascularization density is closely related to clinical symptoms of patients with coronary heart disease.
