Current study of Toll-like receptor and fundus disease
10.3760/cma.j.issn.2095-0160.2013.10.018
- VernacularTitle:眼底病变与Toll样受体的研究进展
- Author:
Xue-mei, CHEN
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
Fundus disease;
Angiogenesis;
Inflammation
- From:
Chinese Journal of Experimental Ophthalmology
2013;31(10):988-991
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors (TLRs) can recognize pathogens associated molecular of micro-organisms,leading to activation of the downstream signal transduction pathway and participate in innate and adaptive immune response.TLRs can also recognize endogenous danger signaling molecule and therefore be involved in pathogenesis of many low-grade chronic inflammatory and autoimmune diseases.TLRs are always expressed on immune cells,and recent studies confirmed that retinal pigment epithelial (RPE) cells also express TLRs.This review focuses on the research progress of fundus diseases and TLRs,such as the recognition of exogenous pathogenic microorganisms and endogenous danger signals in fundus,induction of inflammatory response,phagocytosis of photoreceptor outer segment by RPE and angiogenesis of fundus diseases.
