Recent progress in the ubiquitination regulation of transforming growth factor-β/Smads signal transduction pathway in diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2013.09.023
- VernacularTitle:转化生长因子-β/Smads信号转导通路的泛素化调节在糖尿病视网膜病变中的作用
- Author:
Wen-jun, GOU
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Ubiquitin-proteasome pathway;
Transforming growth factor-β/Smads signal transduction pathway
- From:
Chinese Journal of Experimental Ophthalmology
2013;31(9):902-904
- CountryChina
- Language:Chinese
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Abstract:
Diabetic retinopathy (DR) is one of the common and serious diabetic complications,with a complex nosogenesis.Studies have shown that transforming growth factor-β (TGF-β) participates in the occurrence and development of DR,and Smads protein is able to mediate and activate TGF-β/Smads signal transduction pathway and further involves in the pathogenesis of DR.Smurf is one of the ubiquitin ligases in ubiquitin-proteasome pathway,and it is clarified to regulate TGF-β/Smads signal transduction pathway degradation.At present,the study on the relationship between TGF-β/Smads pathway and DR has made great progress.The role of ubiquitin-proteasome pathway regulating TGF-β/Smads signal transduction pathway in DR is reviewed in this article.
