MicroRNA and fundus diseases
10.3760/cma.j.issn.2095-0160.2013.09.022
- VernacularTitle:微小RNA与眼底疾病
- Author:
XIAO, WEI
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Fundus disease;
Gene expression regulation
- From:
Chinese Journal of Experimental Ophthalmology
2013;31(9):897-901
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNAs) are endogenous,small and noncoding regulatory RNAs,which widely exist in eukaryotes.MiRNAs regulate the expression of target gene by translating inhibition or mRNA destabilization.MiRNAs have been recognized as a major regulatory fashion of post-transcriptional gene expression and play important roles in many cellular biological processes,including cellular proliferation,diffcrentiation,cell death.Alteration of expression and/or dysregulation of miRNAs are related to a wide variety of severe fundus diseases,such as diabetic retinopathy,age-related macular degeneration and retinoblastoma.This review aimed to provide a summary of the recent progress in the effect of miRNAs on fundus diseases.
