Advance in recombinant adeno-associated virus mediated gene therapy for color blindness
10.3760/cma.j.issn.2095-0160.2013.09.018
- VernacularTitle:重组腺相关病毒介导遗传性色盲基因治疗的研究进展
- Author:
Hong-xia, YANG
;
Yi-guo, QIU
- Publication Type:Journal Article
- Keywords:
Color blindness;
Gene therapy;
Cone;
Retina;
Cyclic nucleotide-gated ion channel;
Adeno-associated virus
- From:
Chinese Journal of Experimental Ophthalmology
2013;31(9):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Color blindness represents a group of vision disorders characterized by lack of ability to distinguish different colors.The inherited color blindness has been regarded as incurable for a long period of time.Recently,adeno-associated virus(AAV) mediated gene therapy has successfully restored cone system vision in animal models with color blindness caused by different gene mutations.These mutations are presented in human color blindness patients.It is predicted that gene therapy will become a novel treatment for these color blindness victims.In addition,a single gene transfer may achieve long-term correction of color deficiency.
