Research progress and prospect of human β-defensin 3 and its derivatives in ophthalmology

VernacularTitle:人β-防御素3及其衍生物的研究进展及在眼科的应用
Author: Yue-Qin, FANG
Publication Type:Journal Article
Keywords: Human β-defensin 3; Derivant; Ocular surface inflammation; Protein synthesis; Broad-spectrum antimicrobial activity
From: Chinese Journal of Experimental Ophthalmology 2013;31(10):997-1000
CountryChina
Language:Chinese
Abstract: Currently,antimicrobial resistance has become an urgent global public health problem.Human defensin,a family of innate immune peptides,plays an important role in the control of infectious disease because of its low resistance to microbiological infection.However,so far there is seldom report on industrial production of bioactive defensin.Human β-defensin 3 (HBD3) is a member of human innate antimicrobial peptides.It has broad-spectrum antimicrobial activity and function in a variety of inflammation diseases.In addition,HBD3 is considered as a good candidate for antibiotics,because it has a strong killing activity to antibiotics-resistant microbes and resistance to highsalt environment,it is especially valuable for the treatment of ocular surface inflammatory diseases.This review covers the in vitro research on the production of HBD3,optimization of structure-activity and its antimicrobial potential for ocular surface infection,which may provide a supportive evidence for the commercial production of HBD3 and other antimicrobial peptides in biopharmaceutical area.