Current progression in effects of matrix metalloproteinases and tissue inhibitor of metalloproteinases on agerelated macular degeneration
10.3760/cma.j.issn.2095-0160.2013.08.020
- VernacularTitle:基质金属蛋白酶和组织金属蛋白酶抑制剂在年龄相关性黄斑变性发病中的作用
- Author:
Ren-pan, ZENG
- Publication Type:Journal Article
- Keywords:
Age-related macular degeneration;
Matrix metalloproteinase;
Tissue inhibitor of metalloproteinase;
Elastin-derived peptide;
Angiogenesis;
Choroidal neovascularization
- From:
Chinese Journal of Experimental Ophthalmology
2013;31(8):792-797
- CountryChina
- Language:Chinese
-
Abstract:
Age-related maculadegeneration (AMD) ione of majoretinal diseaseleading to central vision loss.Apresent,the pathogenesiof AMD ibelow understood.Ovethe pasdecade years,dysmetabolism of extracellulamatrix (ECM) regulated by matrix metalloproteinase(MMPs) and tissue inhibitoof metalloproteinase(TIMPs) system play an importanrole in the pathogenesiof AMD.The imbalance of MMPand TIMPleadto differenpathological changeof Bruch 'membrane,which involvein drusen formation and regulatechoroidal neovascularization (CNV).The level of elastin-derived peptides(EDPs) reflectthe level and activity of M MPs,and the elevated level of EDPincreasethe risk of early AMD to advance neovasculaAMD.Thiarticle reviewthe research progression of MMPs,TIMPand the elastin-derived peptideand in AMD.