Research progress in the treatment of retinitis pigmentosa degeneration with phosphodiesterase 6b gene mutation mouse
10.3760/cma.j.issn.2095-0160.2013.07.019
- VernacularTitle:视网膜变性Pde6b基因突变小鼠治疗的研究进展
- Author:
Juan-juan, HAN
- Publication Type:Journal Article
- Keywords:
Retinal degeneration;
Mouse model;
Phosphodiesterase;
Therapy
- From:
Chinese Journal of Experimental Ophthalmology
2013;(7):693-696
- CountryChina
- Language:Chinese
-
Abstract:
In the past decades,more and more mutant genes that cause inherited retinal diseases have been found.Meanwhile,many naturally occurring animal models have also been found to show similar gene mutations and phenotypes as the human inherited retinal diseases,which have led to the development of a variety of therapeutic strategies for those traditionally incurable inherited diseases.These models include rod degeneration (rd) mice,such as rd1 model,rd10 model and nmf137.To compare the efficacy of these strategies,this article briefly reviews the recent progress in the treatment of the mouse models with mutations in the subunit of rod phosphodiesterase (Pde6b)gene by pharmaceutical,stem cell and gene therapy in order to find a more effective treatment for retinal degeneration.
