The effects of chemokines in ocular neovascular diseases
10.3760/cma.j.issn.2095-0160.2013.05.025
- VernacularTitle:趋化因子与眼部新生血管性疾病研究进展
- Author:
Meng-ru, SU
- Publication Type:Journal Article
- Keywords:
Chemokines;
Choroidal neovascularization;
Diabetic retinopathy;
Age-related macular degeneration
- From:
Chinese Journal of Experimental Ophthalmology
2013;(5):517-520
- CountryChina
- Language:Chinese
-
Abstract:
Chemokine is a family of small chemotactic cytokines.Chemokine mainly locates in neutrophile granulocyte,monocyte,macrophage,T lymphocyte and B lymphocyte,and some cells and immunoactive cells also secret cytokines.Researches showed that chemokine plays important roles in many patho-physiological activities,such as inflammatory response,infection procedure,wound healing,regulation of immunity,angiogenesis,invasion and metastases of cancer,etc..Some chemokine factors,such as hyperglycemia,hypoxia,oxidative stress,stimulate the ocular histiocytes to up-regulate the expressions of CXC chemokines and CC chemokines,which participate in the development of choroidal neovascularization and ocular neovascular diseases.This article reviews current progress in chemokine and the relationship between chemokines and ocular neovascular diseases,especially in diabetic retinopathy (DR) and age-related macular degeneration (AMD) etc..
