Advances in the study of mincle, a new C-type lectin receptor
10.3760/cma.j.issn.2095-0160.2013.07.017
- VernacularTitle:新型C型凝集素受体mincle的研究进展
- Author:
Wen-jun, CHEN
- Publication Type:Journal Article
- Keywords:
Immune response;
Inflammation;
C-type lectin receptor;
Mincle;
Ligand;
Signal transduction
- From:
Chinese Journal of Experimental Ophthalmology
2013;(7):688-691
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage-inducible C-type lectin (mincle receptor) is a novel unclassical C-type lectin receptor member,which is mainly expressed on the surface of antigen presenting cells.Under the stimulation of fungus,mycobacterium tuberculosis and necrotic cells,mincle receptor plays anatural immune effect in host body by binding to relevant ligand and activate nuclear factor-κB (NF-κB) signaling pathway,which promotes the expression of many inflammatory factors.Up to now,the laboratory and clinical studies on mincle receptor and infected diseases is being a hot topic.However,these study is lack in ophthalmology.Understanding the association of mincle receptor to infected eye diseases will offer a new approach to the immunotherapy.The basic concept,acting mechanism,its relationship to inflammatory eye diseases and outlook in ophthalmology of mincle receptor were reviewed in this paper.
