Inducible costimulatory molecule and autoimmune uveitis
10.3760/cma.j.issn.2095-0160.2013.07.015
- VernacularTitle:可诱导共刺激分子与自身免疫性葡萄膜炎
- Author:
Le, YANG
- Publication Type:Journal Article
- Keywords:
Autoimmune uveitis;
Inducible costimulatory molecule;
Helper T cell;
Regulatory T cell
- From:
Chinese Journal of Experimental Ophthalmology
2013;(7):682-686
- CountryChina
- Language:Chinese
-
Abstract:
Inducible costimulatory molecule (ICOS) is one of the costimulatory molecules CD28 superfamily and is upregulated on the surface of T cells following T cell activation.ICOS initiates costimulatory signals after binds with its ligand (ICOSL) and ICOS/ICOSL promote activation of T cells proliferation,differentiation and cytokine production.Clinical and laboratory researches documented that ICOS/ICOSL plays significant roles in various autoimmune diseases,similarly,it plays critical effects on the outcome and evolution of autoimmune uveitis (AIU) and Behcet disease.To further study the influence and mechanism of ICOS/ICOSL pathway on AIU is of helpful for finding out a new therapeutic approach of AIU.This paper reviewed the basic concept of ICOS,the relationship between ICOS/ICOSL pathway and effector cell,the outlook of ICOS/ICOSL in the treatment of AIU.
