Extracellular matrix and posterior capsular opacification
10.3760/cma.j.issn.2095-0160.2013.04.022
- VernacularTitle:细胞外基质与晶状体后囊膜混浊
- Author:
Yan-yan, ZHANG
;
Hong-ling, LIU
- Publication Type:Journal Article
- Keywords:
Extracellular matrix;
Posterior capsular opacification;
Lens epithelial cells
- From:
Chinese Journal of Experimental Ophthalmology
2013;(4):400-403
- CountryChina
- Language:Chinese
-
Abstract:
Posterior capsular opacification (PCO) is one of the major complications of modern cataract surgery.Multiple studies had demonstrated that the extracellular matrix (ECM) plays an important role in the generation and development of PCO.A variety of ECM components,including fibronectin (FN),laminin (LN),collagen,lumican,osteoponin (OPN),decorin,hyaluronic acid and vimentin,affect the biological properties of lens epithelial cells (LECs) through different mechanisms,such as regulating cell migration,adhesion and proliferation.This review focuses on the role of ECM in PCO formation in order to explore the pathogenesis of PCO and provide a potential therapeutic approach for the prevention and management of PCO.
