Diagnositic value of trascranial sonography in detection of Parkinson disease
10.3877/cma.j.issn.1672-6448.2013.06.007
- VernacularTitle:经颅超声成像诊断帕金森病的临床应用价值
- Author:
Chen, LI
;
Wen, HE
;
Hui-qin, ZHANG
;
Li-shu, WANG
;
Hong-xia, ZHANG
;
Ling-gang, CHENG
;
Li-juan, DU
;
Chen-jie, CAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography,Doppler,transcranial;
Parkinson disease;
Substantia nigra;
Mesencephalon
- From:
Chinese Journal of Medical Ultrasound (Electronic Edition)
2013;(6):461-464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of trascranial sonography (TCS) in measuring hyperechogenic substantia nigra ( SN) area and area ratio of SN to midbrain ( S/M) for the diagnosis of Parkinson′s disease( PD).Methods A total of 109 PD patients ( PD group) and 115 normal controls (control group) underwent TCS.The area of midbrain and SN and the area ratio of S/M were measured and compared between PD group and control group .Statistical analysis of the two parameters in predicting PD was performed with receive operating characteristic ( ROC) curves.The sensitivity and specificity of each parameter and their combination were calculated .Results The hyperechogenic SN area and S/M were (0.34 ±0.27)cm 2 and (12.15 ±4.57)%in PD group,whereas (0.14 ±0.08)cm 2 and (6.37 ±3.30)%in control group respectively .The difference between the two groups was statistically significant (t=82.68, 100.83,both P<0.01).ROC analysis showed that using the cut-off of 0.20 cm 2 for SN hyperechogenicity, the sensitivity and specificity were 80.40%and 74.50%.With the cut-off of 7.52%for S/M,the sensitivity and specificity were 89.10% and 63.30%.By using the combination of SN hyperechogenicity≥0.20 cm 2 and S/M>7.52%,the sensitivity was 80.4%and the specificity was 78.6%.Conclusions TCS is a fast, convenient,effective and useful tool for screening PD .The combination of the SN area and S/M provided the best diagnostic parameters.
