Establish of animal model of nonarteritic anterior ischemic optic neuropathy
10.3760/cma.j.issn.2095-0160.2013.01.022
- VernacularTitle:非动脉炎性前部缺血性视神经病变动物模型的制备
- Author:
Wen-juan, WANG
;
Wei-na, MA
- Publication Type:Journal Article
- Keywords:
Nonarteritic anterior ischemic optic neuropathy;
Animal model;
Photodynamics
- From:
Chinese Journal of Experimental Ophthalmology
2013;(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Nonarteritic anterior ischemic optic neuropathy (NAION)is a common optic neuropathy seriously affecting the visual function in the middle-aged and elderly population.However,its pathogenesis is not completely clear,and therefore its treating efficacy is dissatisfactory.The current study on NAION is focused on the establishment of suitable animal model and the pathogenesis.In recent years,the relatively ideal animal models(including rodent and primate) have been established by photodynamic methods,which make people have more in-depth understanding on the pathophysiologic mechanism of NAION and lay the basis for the research of therapies.The selection of experimental animals,various induction methods and existing problems in the creation of NAION animal model were reviewed and analyzed in this artical.
