Research progress in benign lymphoepithelial lesion
10.3760/cma.j.issn.2095-0160.2013.01.023
- VernacularTitle:良性淋巴上皮病变的研究进展
- Author:
Yi-xin, CUI
- Publication Type:Journal Article
- Keywords:
Benign lymphoepithelial lesion;
Lacrimal gland;
Etiology;
Pathogenesis;
Pathology;
Diagnosis;
Differential diagnosis;
Treatment;
Prognosis
- From:
Chinese Journal of Experimental Ophthalmology
2013;(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Benign lymphoepithelial lesion(BLEL) is known as Mikulicz disease.The clinical manifestation of BLEL mainly includes diffuse painless enlargement of the eye or the monocular lachrymal gland.The etiology and pathogenesis of the disease proposed mainly concerns the sex hormone hypothesis,transforming growth factor-β involvement hypothesis,basal cell hyperplasia invasion hypothesis,and IgG4-related hypothesis,etc..The typical pathological changes are infiltration of lymphocytes in the gland,atrophy of the gland tissue,formation of myoepithelial islands within the duct hyperplasia in the gland caused by infiltration of the tubular expansion.There is no uniform diagnosis criterion for this disease up to now,but it needs to be differentiated from idiopathic orbital inflammatory pseudotumor and Sj(o)gren syndrome in clinical diagnosis.The application of glucocorticoid is the primary treating regimen for benign lymphoepithelial lesion.Local radiation therapy and/or surgery extraction are available to patients unsensitive to glucocorticoid therapy.
