The study development of induced pluripotent stem cell in ophthalmology

VernacularTitle:诱导多能干细胞在眼科的研究进展
Author: Xiao, LI
Publication Type:Journal Article
Keywords: Induced pluripotent stem cell; Retinal degeneration disease; Stem cell transplantation
From: Chinese Journal of Experimental Ophthalmology 2012;(11):1040-1043
CountryChina
Language:Chinese
Abstract: Retinal degeneration diseases is an irreversible neurodegenerative impairment.Nowadays,it has become one of the most common causes of blindness,but medical treatments showed little efficiency on these diseases.Recently,some researchers found that a series of transcription factors being capable of reprogramming DNA can reconstruct and induce somatic cells into pluripotent stem cells (iPSCs).The iPSCs not only have great potential of self-renew and differentiation,but also can avoid some critical issues such as ethical restrictions and immune suppression by using embryonic stem cells.Retinal stem cell therapy can also benefit from the ease of surgical access and observation of transplanted cells directly through the clear ocular media.These advantages make it possible for the iPSCs therapy to be a new approach to managing the retinal degenerative diseases in the future.The research history,feature and advantage,induce and directional differentiation of iPSCs were reviewed.