Research progresses in the distribution of ocular tissue of microRNAs and its relationship with oculopathy
10.3760/cma.j.issn.2095-0160.2012.10.024
- VernacularTitle:微小RNAs在眼组织的表达及其与眼科疾病的关系
- Author:
Dong, YANG
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Retina;
Lens;
Cornea;
Eye diseases
- From:
Chinese Journal of Experimental Ophthalmology
2012;(10):956-960
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs(miRNAs) are a newly discovered class of small noncoding RNAs that rcgulate gene expression by translational repression or mRNA degradation.It has become evident that miRNAs are involved in many important biological processes,including tissue differentiation and development,showing a tissue specificity and development-stage specificity.In the other hand,miRNAs play critical roles in neovascularization and a variety of pathophysiological processes,such as pathological angiogenesis,oxidative stress response,immune response and inflammation.Currently,miRNAs of the retina,lens and cornea have been established,and they would be potential therapeutic targets in the eye diseases.Here,the distribution of miRNAs in the eye and their role in ocular diseases were summarized.
