Current research of effect of glutathione S-transferases on eye oxidative damage
10.3760/cma.j.issn.2095-0160.2012.06.021
- VernacularTitle:谷胱甘肽转硫酶在眼部的作用
- Author:
Jiang-li, FAN
- Publication Type:Journal Article
- Keywords:
Glutathione S-transferases;
Oxidative damage/eye;
Gene polymorphism
- From:
Chinese Journal of Experimental Ophthalmology
2012;30(6):566-570
- CountryChina
- Language:Chinese
-
Abstract:
Glutathione S-transferases (GSTs) are large super-gene family.It is traditionally thought to be a kind of electrophilic detoxification substance.However,recent research showed that it has a powerful antioxidant role,but its gene polymorphism is also a risk factor of variety diseases.Researches verified that GSTs are widely found in the epithelial tissue in human and eye tissues,such as iris,ciliary,trabecular meshwork,lens,macula and retina.GSTs play strong preventive and treating roles for many oxidative-induced eye diseases,including primary open-angle glaucoma ( POAG),age-related cataract and age-related macular degeneration ( AMD ).The antioxidative mechanism of GSTs to eye diseases is in study.The current researches about the element concept,distributions in eye tissues,gene polymorphism of GSTs and its relationship with eye oxidative damage were reviewed.
