The immune surveillance function of microglia in tumor
10.3760/ema.j.issn.2095-0160.2011.12.021
- VernacularTitle:小胶质细胞对肿瘤的免疫监视作用
- Author:
Xue, CHEN
- Publication Type:Journal Article
- Keywords:
Microglia;
Immune surveillance;
Central nervous system;
Retina;
Tumor
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(12):1145-1148
- CountryChina
- Language:Chinese
-
Abstract:
As a part of the central nervous system,retina shares many characters of the brain,including many of the functions and dysfunctions of microglia.Microglia plays important roles in multiple inflammatory procedures and degenerative diseases of the central nervous system and retina.Retinal microglia is involved in ocular inflammatory,age-related macular degeneration and diabetic retinopathy.These cells have also been identified in brain tumor and retinoblastoma.They can secrete various cytokines and growth factors that may contribute to the successful immune evasion and therefore promote the growth and invasion of tumor.To better understand the function of microglia is essential for us to develop the immune-based treatment strategies against central nervous system tumor and retinoblastoma.
