Research progress in molecular mechanism of erythropoietin and ischemic retinal disease
10.3760/cma.j.issn.2095-0160.2011.11.025
- VernacularTitle:促红细胞生成素对缺血性视网膜病变分子作用机制的研究进展
- Author:
Huan, CHEN
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Receptor;
Retina/ischemic disease;
Molecular mechanism
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(11):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Recent researches have achieved new progress in the function and signal transduction molecular mechanisms of erythropoietin (EPO).Previous studies confirmed that EPO is an independent angiogenic factor,especially in the development of retinopathy of prematurity (ROP).Recent research found that EPO protect the neurons as a neurotrophic factor.However,in proliferation stage as an angiogenic factor,EPO shares similarities with vascular endothelial growth factor ( VEGF ) in the early phase of diabetes.Besides,a recent study about effects of intravitreal EPO therapy for patients with chronic and progressive diabetic macular edema showed a short-term positive response.Here,the effects and molecular mechanisms of EPO/EPOR system in ischemic retinal disease were reviewed.
