The protective effects of erythropoietin/erythropoietin receptor system on optic nerve and retinal diseases
10.3760/cma.j.issn.2095-0160.2011.08.024
- VernacularTitle:促红细胞生成素及其受体与视神经视网膜疾病
- Author:
Zheng-gao, XIE
;
Chao-rong, ZHUANG
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Erythropoietin receptor;
Optic nerve;
Retina;
Neuroprotection
- From:
Chinese Journal of Experimental Ophthalmology
2011;29(8):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Erythropoietin(EPO) has an anti-apoptotic effect,and promotes the proliferation and differentiation of erythroid progenitor cells. Several studies have indicated that EPO can protect photoreceptor cells from the lightinduced retinal degeneration ;protect retinal neurons from ischemia-reperfusion injury and retinal ganglion cells after acute and chronic ocular hypertension; promote ganglion cell survival and axonal regeneration after optic nerve transaction; attenuate inflammation in multiple sclerosis optic neuritis; reduce the permeability of the retinal barrier and protect retinal neurons in diabetic retinopathy; enhance the stability of hypoxic retinal vessels in retinopathy of prematurity. Herein,we review the distribution of EPO and its receptor in retina,their expression in animal model of retinal diseases,and their effects and mechanisms in protection of retinal neurons and optic nerve.
