Application of epidermal growth factor in corneal injury

VernacularTitle:表皮生长因子在角膜损伤疾病中的应用
Author: Xiao-hua, LIANG
Publication Type:Journal Article
Keywords: Epidermal growth factor; Cornea injury; Corneal epithelial cell; Corneal endothelial cell
From: Chinese Journal of Experimental Ophthalmology 2012;30(9):857-860
CountryChina
Language:Chinese
Abstract: Epidermal growth factor (EGF) is a very important peptide growth factor,which is not only involving in a variety of ocular cell mitosis,proliferation and differentiation,but also participates in mediating the signal transduction between cell and cell,cell and matrix interaction and other biological functions.Corneal injury is a common and frequently occurring disease in ophthalmology,and it would lead to blindness without appropriate treatment.Researches showed that EGF can promote the repair and regeneration of wounded cornea.In recent years,these studies advance from animal experiment stage to clinical stage and also from the morphology evaluation stage to the genetics study stage.This paper provided an overview of EGF concept,its biological effectiveness,its relationship to corneal injury and its clinical application.