Extracellular matrix-related molecule on fundus neovascularization
10.3760/cma.j.issn.2095-0160.2012.04.021
- VernacularTitle:细胞外基质相关分子在眼底新生血管形成中的作用
- Author:
Chao, BI
;
Ting, LIU
- Publication Type:Journal Article
- Keywords:
Retinal neovascularization;
Choroidal neovascularization;
Extracellular matrix;
Integrin;
Urokinase-type plasminogen activator;
Matrix metalloproteinase
- From:
Chinese Journal of Experimental Ophthalmology
2012;30(4):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Neovascularization is the main cause of the vision loss of the patients sufferring from proliferative diabetic retinopathy,retinopathy of prematurity and age-related macular degeneration.It is proved that collagen and elastin in the extracellular matrix contribute to the choroidal and retinal neovascularization in vitro and in vivo.Among the extracellular matrix-related adhesion molecules,integrin α5β1 could enhance the cell adhesion and hyperplasy,while its inhibitors could restrain the choroidal and retinal neovascularization in vivo,so are the inhibitors of the integrin α V β3 and α V β5.Selectins and intercellular adhesion molecule-1 mainly affect the neovascularization as the medium between the endothelial cells and the leucocytes.It is demonstrated that the extracellular matrix degradationrelated serine proteinases (mainly urokinase-type plasminogen activator ) /matrix metalloproteinases (mainly MMP-2 and MMP-9)also could induce the choroidal and retinal neovascularization in vitro and in vivo.Furthermore,type-1 plasminogen activator inhibitor and tissue inhibitor of metalloproteinase could prevent that and the further study of the extracellular matrix-related molecules would bring out new insights and methods for the precaution and treatement of the ocular neovascularization.
